Eco-friendly Novel Kinetic Procedures for Spectrophotometric Analysis of Antihistamine Drug Part II. Validation, Practicality, and Green Perspective

Abstract

— A new kinetic technique to quantify desloratadine (DES) in dosage forms was interesting through the reaction of DES with 1,2-naphthoquinone-4-sulphonate (NQS), in an aqueous medium of borax at pH 9. The formed stable product was followed by measuring the increased absorbance with time at 485 nm. Four kinetic procedures were applied for the determination of DES. The initial rate and fixed-time (15 min) methods are the most suitable for plotting calibration graphs in the concentration ranges 2.50–35.00 and 2.50–37.50 μg/mL, with detection limits of 0.165 and 0.128 μg/mL, respectively. The molar absorptivity for the method was found to be 6.04×103 L/mol cm. The suggested kinetic methods were applied to determine DES in tablets. They were found to be more sustainable, eco-friendly, efficient, and practicable than the reported BP method, by applying green and white tools: AES, AGREE, AGREEprep, GAPI, and RGB, making it a safer alternative to be considered.