Synthesis of Thiazolidine Derived from Ninhydrin and 3-Methoxyphenyl Isothiocyanate and Study of Their Biological Effect

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Published: 2025-09-17
Updated: 2025-09-17
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2025-09-17 (4)
DOI: https://doi.org/10.5678/kn45tb09
Keywords:
Schiff base, Thiazolidine-4-one, Isothiocyanates, Escherichia coli, Staphylococcus aureus

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Deaa Gamal Alden Alasaad
Department of Chemistry, Faculty of Science, University of Idlib, Syria
https://orcid.org/0009-0008-4173-3741
Ayham Al-Jundi
Faculty of Pharmacy, Alshmal Private University, Idlib, Syria
https://orcid.org/0009-0005-7801-0350
Anber M. ANBER
Department of Chemistry, Faculty of Science, Erciyes University, Kayseri 38039, Turkey- Department of Chemistry, Faculty of Pharmacy, Idlib University, Idlib, Syria.
https://orcid.org/0000-0002-9841-8979

Abstract

A biologically effective chemical structure was obtained from ninhydrin and isothiocyanate. At the first stage of the synthesis, isothiocyanate was combined with hydrazine to obtain a hydrazine derivative, and then its reactivity in the second stage with ninhydrin was used to obtain a new derivative of the Schiff base. At the third stage, dimethylacetylene dicarboxylate (DMAD)was added to the prepared Schiff base, and oxathiozolidine derivatives were obtained. The prepared compounds were characterized using proton nuclear magnetic resonance (¹H NMR), carbon nuclear magnetic resonance (13C NMR), Mass spectrometry, and infrared spectroscopy (FT-IR). Also, the biological activity of these compounds was studied at a series of concentrations against Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive) bacterial strains. Using the diffusion method, some compounds showed biological effects that ranged from medium to good on these germs.

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Vol. 1 No. 1 (2025): August Issue

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Articles

Author Biographies

Deaa Gamal Alden Alasaad , Department of Chemistry, Faculty of Science, University of Idlib, Syria

Prof. Diaa Jamal Al-Deen Al-Asaad is a dedicated chemistry educator with over a decade of teaching experience across public and private institutions in Syria. He holds a Bachelor's degree in Pure Chemistry and a Diploma in Educational Qualification from Al-Baath University. Currently, he is pursuing his Master's degree in General Chemistry at Idlib University. His teaching career includes roles at Al-Baath University, Idlib University, and Al-Shamal University, where he has consistently demonstrated his ability to simplify complex scientific content for learners of all levels. Diaa is ICDL-certified and brings strong communication and instructional skills to his work, making him a valued contributor to academic settings. He is proficient in Arabic and has intermediate English and beginner-level Turkish proficiency. With a passion for scientific education and curriculum delivery, he plays a crucial role in developing students' understanding of chemistry in northern Syria's higher education sector.

Ayham Al-Jundi, Faculty of Pharmacy, Alshmal Private University, Idlib, Syria

Dr. Ayham Al-Jundi is a seasoned academic and industry professional in the field of applied chemistry and pharmaceutical sciences. He earned his Bachelor's degree in Applied Chemistry from the University of Aleppo, followed by a Master's in Organic Chemical Industries (2012), and a PhD in Applied Chemistry (2016). Dr. Al-Jundi has over 15 years of combined experience in academia and the pharmaceutical industry. He has taught at several universities, including Aleppo and Ibla Private University, and currently serves as Head of the Pharmacy Department at Al-Shamal Private University. His academic portfolio includes subjects such as pharmaceutics, pharmaceutical synthesis, and industrial pharmacy. In parallel, he has held roles in manufacturing and pharmaceutical sales with notable companies like Rama Pharma. Dr. Al-Jundi is also known for organizing academic symposia and advancing scientific discourse. He brings bilingual proficiency (Arabic and English), strong technical expertise, and a deep commitment to pharmaceutical education and applied research.

Anber M. ANBER, Department of Chemistry, Faculty of Science, Erciyes University, Kayseri 38039, Turkey- Department of Chemistry, Faculty of Pharmacy, Idlib University, Idlib, Syria.

Dr. Anber M. Anber is a distinguished scholar in chemistry and education, holding dual PhDs—one in Organic Chemistry from Erciyes University (Turkey) and another in Curriculum and Instruction from Al-Madinah International University 

(Malaysia). His academic and professional journey spans teaching roles in Idlib and Al-Shamal Universities, supervising development at JOCHEM Chemicals, and participating in international workshops through the Cara Syria Programme. With a Master's in Education and Chemistry, and a strong background in laboratory research and pedagogy, Dr. Anber combines scientific rigor with educational innovation. His publication record includes impactful research in drug synthesis, cancer treatment agents, and science education challenges in conflict-affected regions. He is fluent in Arabic and English and has advanced Turkish proficiency; he actively bridges chemistry and curriculum development. Dr. Anber also plays a consultative role in chemical R&D and educational reform. He remains a respected academic voice advancing scientific knowledge and education quality in the Middle East.

How to Cite

Synthesis of Thiazolidine Derived from Ninhydrin and 3-Methoxyphenyl Isothiocyanate and Study of Their Biological Effect. (2025). Research Journal of Maaref University of Applied Sciences, 1(1), Pages 5. https://doi.org/10.5678/kn45tb09 (Original work published 2025)

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