Synthesis of Thiazolidine Derived from Ninhydrin and 3-Methoxyphenyl Isothiocyanate and Study of Their Biological Effect

Abstract

A biologically effective chemical structure was obtained from ninhydrin and isothiocyanate. At the first stage of the synthesis, isothiocyanate was combined with hydrazine to obtain a hydrazine derivative, and then its reactivity in the second stage with ninhydrin was used to obtain a new derivative of the Schiff base. At the third stage, dimethylacetylene dicarboxylate (DMAD)was added to the prepared Schiff base, and oxathiozolidine derivatives were obtained. The prepared compounds were characterized using proton nuclear magnetic resonance (¹H NMR), carbon nuclear magnetic resonance (13C NMR), Mass spectrometry, and infrared spectroscopy (FT-IR). Also, the biological activity of these compounds was studied at a series of concentrations against Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive) bacterial strains. Using the diffusion method, some compounds showed biological effects that ranged from medium to good on these germs.